I feel most challenged when praying for my friends in India who are under such terrifying persecution -- beaten, families threatened, churches and houses burned down -- and other things we really can't imagine or relate to.
Certain things are obvious I could pray for, you might think. But it never seems enough, or complete...the closest I can get to feeling like I'm on the right track is when I read (and then pray on behalf of my friends) 2 Thes 2&3:
...May our Lord Jesus Christ Himself and God our Father, who loved us and by His grace gave us eternal encouragement and good hope, encourage your hearts and strengthen you in every good deed and word.
(Now this part I've changed a little to pray on their behalf)
Finally, brothers, I pray for you that the message of the Lord may spread rapidly and be honored, just as it was with you.
And I pray that you may be delivered from wicked and evil men, for not everyone has faith.
But the Lord is faithful, and He will strengthen and protect you from the evil one...
May the Lord direct your hearts into God's love and Christ's perseverance.